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Both V(D)J Coding Ends but Neither Signal End Can Recombine at the bcl-2 Major Breakpoint Region, and the Rejoining Is Ligase IV Dependent

The t(14;18) chromosomal translocation is the most common translocation in human cancer, and it occurs in all follicular lymphomas. The 150-bp bcl-2 major breakpoint region (Mbr) on chromosome 18 is a fragile site, because it adopts a non-B DNA conformation that can be cleaved by the RAG complex. Th...

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Autors principals: Raghavan, Sathees C., Hsieh, Chih-Lin, Lieber, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190333/
https://ncbi.nlm.nih.gov/pubmed/16024785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.15.6475-6484.2005
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