Binding of Calmodulin to the Carboxy-Terminal Region of p21 Induces Nuclear Accumulation via Inhibition of Protein Kinase C-Mediated Phosphorylation of Ser153

Intracellular localization plays an important role in the functional regulation of the cell cycle inhibitor p21. We have previously shown that calmodulin binds to p21 and that calmodulin is essential for the nuclear accumulation of p21. Here, we analyze the mechanism of this regulation. We show that...

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Detalhes bibliográficos
Main Authors: Rodríguez-Vilarrupla, Aina, Jaumot, Montserrat, Abella, Neus, Canela, Núria, Brun, Sonia, Díaz, Carmen, Estanyol, Josep M., Bachs, Oriol, Agell, Neus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190259/
https://ncbi.nlm.nih.gov/pubmed/16055744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.16.7364-7374.2005
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