Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid

BACKGROUND: Interleukin 1 (IL-1) is a key mediator of immune responses in health and disease. Although classically the function of IL-1 has been studied in the systemic immune system, research in the past decade has revealed analogous roles in the CNS where the cytokine can contribute to the neuroin...

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Bibliographic Details
Main Authors: Craft, Jeffrey M, Watterson, D Martin, Hirsch, Emmet, Van Eldik, Linda J
Format: Artigo
Language:Inglês
Published: BioMed Central 2005
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190207/
https://ncbi.nlm.nih.gov/pubmed/15967035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-2-15
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