Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

Severe acute respiratory syndrome (SARS) is caused by an emergent coronavirus (SARS-CoV), for which there is currently no effective treatment. SARS-CoV mediates receptor binding and entry by its spike (S) glycoprotein, and infection is sensitive to lysosomotropic agents that perturb endosomal pH. We...

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Main Authors: Simmons, Graham, Gosalia, Dhaval N., Rennekamp, Andrew J., Reeves, Jacqueline D., Diamond, Scott L., Bates, Paul
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2005
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1188015/
https://ncbi.nlm.nih.gov/pubmed/16081529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505577102
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