An evolutionary constraint: Strongly disfavored class of change in DNA sequence during divergence of cis-regulatory modules

The DNA of functional cis-regulatory modules displays extensive sequence conservation in comparisons of genomes from modestly distant species. Patches of sequence that are several hundred base pairs in length within these modules are often seen to be 80–95% identical, although the flanking sequence...

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Bibliographic Details
Main Authors: Cameron, R. Andrew, Chow, Suk Hen, Berney, Kevin, Chiu, Tsz-Yeung, Yuan, Qiu-Autumn, Krämer, Alexander, Helguero, Argelia, Ransick, Andrew, Yun, Mirong, Davidson, Eric H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1188003/
https://ncbi.nlm.nih.gov/pubmed/16087870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505291102
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