Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription

BACKGROUND: HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA. CDK9 is maintained in dephosphorylated state by TFIIH and undergo phosphorylation upon the dissociation of TFIIH. Thus, dephosp...

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Autori principali: Ammosova, Tatyana, Washington, Kareem, Debebe, Zufan, Brady, John, Nekhai, Sergei
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187922/
https://ncbi.nlm.nih.gov/pubmed/16048649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-2-47
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