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Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability

Anaphase promoting complex/cyclosome (APC/C)-mediated proteolysis is essential for chromosome segregation, mitotic exit, and G1 entry. Here, we show the importance of APC/C in the control of dTTP pool size in mammalian cells. Two enzymes, thymidine kinase 1 (TK1) and thymidylate kinase (TMPK), invol...

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Bibliografske podrobnosti
Main Authors: Ke, Po-Yuan, Kuo, Yuan-Yeh, Hu, Chuan-Mei, Chang, Zee-Fen
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1186191/
https://ncbi.nlm.nih.gov/pubmed/16103219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1322905
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