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N-terminal cleavage of proTGFα occurs at the cell surface by a TACE-independent activity
ProTGFα (transforming growth factor α precursor) maturation and conversion into soluble TGFα is a complex process that involves three proteolytic steps. One, that occurs co-translationally, eliminates the signal sequence. Another, occurring at the juxtamembrane domain, solubilizes TGFα. A third clea...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Portland Press Ltd.
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1184548/ https://ncbi.nlm.nih.gov/pubmed/15777285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041128 |
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