N-terminal cleavage of proTGFα occurs at the cell surface by a TACE-independent activity

ProTGFα (transforming growth factor α precursor) maturation and conversion into soluble TGFα is a complex process that involves three proteolytic steps. One, that occurs co-translationally, eliminates the signal sequence. Another, occurring at the juxtamembrane domain, solubilizes TGFα. A third clea...

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Bibliographic Details
Main Authors: Juanes, Pedro P., Ferreira, Laura, Montero, Juan Carlos, Arribas, Joaquín, Pandiella, Atanasio
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184548/
https://ncbi.nlm.nih.gov/pubmed/15777285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041128
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