Kinetic analysis of specificity of duplex DNA targeting by homopyrimidine peptide nucleic acids.

A simple theoretical analysis shows that specificity of double-stranded DNA (dsDNA) targeting by homopyrimidine peptide nucleic acids (hpyPNAs) is a kinetically controlled phenomenon. Our computations give the optimum conditions for sequence-specific targeting of dsDNA by hpyPNAs. The analysis shows...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Demidov, V V, Yavnilovich, M V, Frank-Kamenetskii, M D
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1997
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1184472/
https://ncbi.nlm.nih.gov/pubmed/9168050
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