Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

BACKGROUND: Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet, though glutathione (GSH) is likely to have a role for the resistance to occur....

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Bibliografiske detaljer
Main Authors: Akan, Ilhan, Akan, Selma, Akca, Hakan, Savas, Burhan, Ozben, Tomris
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2005
Fag:
Primary Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183228/
https://ncbi.nlm.nih.gov/pubmed/16042792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-5-22
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