Tyrosine Phosphorylation of the Tio Oncoprotein Is Essential for Transformation of Primary Human T Cells

Human T cells are transformed to antigen-independent permanent growth in vitro upon infection with herpesvirus saimiri subgroup C strains. The viral oncoproteins required for this process, StpC and Tip, could be replaced by Tio, the oncoprotein of herpesvirus ateles. Here we demonstrate that prolife...

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Detalhes bibliográficos
Main Authors: Albrecht, Jens-Christian, Müller-Fleckenstein, Ingrid, Schmidt, Monika, Fleckenstein, Bernhard, Biesinger, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Transformation and Oncogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182665/
https://ncbi.nlm.nih.gov/pubmed/16051843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.16.10507-10513.2005
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