Growth Transformation of Human T Cells by Herpesvirus Saimiri Requires Multiple Tip-Lck Interaction Motifs

Lymphoma induction and T-cell transformation by herpesvirus saimiri strain C488 depends on two viral oncoproteins, StpC and Tip. The major interaction partner of Tip is the protein tyrosine kinase Lck, a key regulator of T-cell activation. The Lck binding domain (LBD) of Tip comprises two interactio...

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Main Authors: Heck, Elke, Friedrich, Ute, Gack, Michaela U., Lengenfelder, Doris, Schmidt, Monika, Müller-Fleckenstein, Ingrid, Fleckenstein, Bernhard, Ensser, Armin, Biesinger, Brigitte
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Transformation and Oncogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617286/
https://ncbi.nlm.nih.gov/pubmed/17005671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01112-06
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