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Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells
Huntington's disease is a progressive neurodegenerative disorder caused by a polyglutamine repeat expansion in the first exon of the huntingtin (Htt) protein. N-terminal Htt peptides with polyglutamine tracts in the pathological range (51–122 glutamines) form high-molecular-weight protein aggre...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1182404/ https://ncbi.nlm.nih.gov/pubmed/16040812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409283102 |
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