Formation of morphologically similar globular aggregates from diverse aggregation-prone proteins in mammalian cells

Huntington's disease is a progressive neurodegenerative disorder caused by a polyglutamine repeat expansion in the first exon of the huntingtin (Htt) protein. N-terminal Htt peptides with polyglutamine tracts in the pathological range (51–122 glutamines) form high-molecular-weight protein aggre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mukai, Hideyuki, Isagawa, Takayuki, Goyama, Emiko, Tanaka, Shuhei, Bence, Neil F., Tamura, Atsuo, Ono, Yoshitaka, Kopito, Ron R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182404/
https://ncbi.nlm.nih.gov/pubmed/16040812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409283102
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