Lowe Syndrome Protein OCRL1 Interacts with Clathrin and Regulates Protein Trafficking between Endosomes and the Trans-Golgi Network

Oculocerebrorenal syndrome of Lowe is caused by mutation of OCRL1, a phosphatidylinositol 4,5-bisphosphate 5-phosphatase localized at the Golgi apparatus. The cellular role of OCRL1 is unknown, and consequently the mechanism by which loss of OCRL1 function leads to disease is ill defined. Here, we s...

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Hlavní autoři: Choudhury, Rawshan, Diao, Aipo, Zhang, Fang, Eisenberg, Evan, Saint-Pol, Agnes, Williams, Catrin, Konstantakopoulos, Athanasios, Lucocq, John, Johannes, Ludger, Rabouille, Catherine, Greene, Lois E., Lowe, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182289/
https://ncbi.nlm.nih.gov/pubmed/15917292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-02-0120
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