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Nucleotide exchange and excision technology (NExT) DNA shuffling: a robust method for DNA fragmentation and directed evolution

DNA shuffling is widely used for optimizing complex properties contained within DNA and proteins. Demonstrated here is the amplification of a gene library by PCR using uridine triphosphate (dUTP) as a fragmentation defining exchange nucleotide with thymidine, together with the three other nucleotide...

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Bibliografiske detaljer
Main Authors: Müller, Kristian M., Stebel, Sabine C., Knall, Susanne, Zipf, Gregor, Bernauer, Hubert S., Arndt, Katja M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182171/
https://ncbi.nlm.nih.gov/pubmed/16061932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gni116
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