The G/G Genotype of a Resistin Single-Nucleotide Polymorphism at −420 Increases Type 2 Diabetes Mellitus Susceptibility by Inducing Promoter Activity through Specific Binding of Sp1/3

Insulin resistance is a major cause of type 2 diabetes mellitus (T2DM). Resistin, an adipocyte-secreted hormone, antagonizes insulin. Transgenic mice that overexpress the resistin gene (Retn) in adipose tissue are insulin-resistant, whereas Retn (−/−) mice show lower fasting blood glucose, suggestin...

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Detaylı Bibliyografya
Asıl Yazarlar: Osawa, Haruhiko, Yamada, Kazuya, Onuma, Hiroshi, Murakami, Akiko, Ochi, Masaaki, Kawata, Hiroko, Nishimiya, Tatsuya, Niiya, Toshiyuki, Shimizu, Ikki, Nishida, Wataru, Hashiramoto, Mitsuru, Kanatsuka, Azuma, Fujii, Yasuhisa, Ohashi, Jun, Makino, Hideichi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society of Human Genetics 2004
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182055/
https://ncbi.nlm.nih.gov/pubmed/15338456
Etiketler: Etiketle
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