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Crohn Disease: Frequency and Nature of CARD15 Mutations in Ashkenazi and Sephardi/Oriental Jewish Families

Crohn disease (CD), an inflammatory bowel disease, is a multifactorial trait with the highest frequency in Ashkenazi Jewish (AJ) individuals of Central European origin. Recently, three common predisposing CARD15 mutations (R702W, G908R, and 1007fs) and a polymorphism (P268S) were identified. To dete...

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Autori principali: Tukel, Turgut, Shalata, Adel, Present, Daniel, Rachmilewitz, Daniel, Mayer, Lloyd, Grant, Deniera, Risch, Neil, Desnick, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Human Genetics 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181940/
https://ncbi.nlm.nih.gov/pubmed/15024686
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