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Defective fast inactivation recovery and deactivation account for sodium channel myotonia in the I1160V mutant.

The skeletal muscle sodium channel mutant I1160V cosegregates with a disease phenotype producing myotonic discharges (observed as muscle stiffness) that are worsened by elevated K+ levels but unaffected by cooling. The I1160V alpha-subunit was co-expressed with the beta1-subunit in Xenopus oocytes....

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Detalhes bibliográficos
Main Authors: Richmond, J E, VanDeCarr, D, Featherstone, D E, George, A L, Ruben, P C
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1181090/
https://ncbi.nlm.nih.gov/pubmed/9336185
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