Linkage Analysis of Extremely Discordant and Concordant Sibling Pairs Identifies Quantitative-Trait Loci That Influence Variation in the Human Personality Trait Neuroticism

Several theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic linkage in complex traits. Here, we report a genetic linkage scan using extremely discordant and con...

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Hauptverfasser: Fullerton, Jan, Cubin, Matthew, Tiwari, Hemant, Wang, Chenxi, Bomhra, Amarjit, Davidson, Stuart, Miller, Sue, Fairburn, Christopher, Goodwin, Guy, Neale, Michael C., Fiddy, Simon, Mott, Richard, Allison, David B., Flint, Jonathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Human Genetics 2003
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180351/
https://ncbi.nlm.nih.gov/pubmed/12612864
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