Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila

Parkin, an E3 ubiquitin ligase, has been found to be responsible for autosomal recessive juvenile parkinsonism characterized primarily by selective loss of dopaminergic neurons with subsequent defects in movements. However, the molecular mechanisms underlying this neuron loss remain elusive. Here, w...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cha, Guang-Ho, Kim, Sunhong, Park, Jeehye, Lee, Eunji, Kim, Myungjin, Lee, Sung Bae, Kim, Jin Man, Chung, Jongkyeong, Cho, Kyoung Sang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177361/
https://ncbi.nlm.nih.gov/pubmed/16002472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500346102
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