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Physicochemical properties of vancomycin and iodovancomycin and their complexes with diacetyl-l-lysyl-d-alanyl-d-alanine

Electrometric and spectrophotometric titrations showed vancomycin to contain groups having pK values of about 2.9, 7.2, 8.6, 9.6, 10.5 and 11.7. Of these the four last-named were phenolic. Titration above pH11 and below pH1 was irreversible and antibiotic potency was destroyed. Combination with the...

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Detalhes bibliográficos
Main Authors: Nieto, M., Perkins, H. R.
Formato: Artigo
Idioma:Inglês
Publicado em: 1971
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177078/
https://ncbi.nlm.nih.gov/pubmed/5124385
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