Structural instability caused by a mutation at a conserved arginine in the α-crystallin domain of Chinese hamster heat shock protein 27

Mutations in the α-crystallin domain of 4 of the small heat shock proteins (sHsp) (Hsp27/HspB1, αA-crystallin/ HspB4, αB-crystallin/HspB5, and HspB8) are responsible for dominant inherited diseases in humans. One such mutation at a highly conserved arginine residue was shown to cause major conformat...

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Bibliographic Details
Main Authors: Chávez Zobel, Aura T., Lambert, Herman, Thériault, Jimmy R., Landry, Jacques
Format: Artigo
Language:Inglês
Published: Cell Stress Society International 2005
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176474/
https://ncbi.nlm.nih.gov/pubmed/16038412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1379/CSC-102.1
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