The HRDC domain of BLM is required for the dissolution of double Holliday junctions

Bloom's syndrome is a hereditary cancer-predisposition disorder resulting from mutations in the BLM gene. In humans, BLM encodes one of five members of the RecQ helicase family. One function of BLM is to act in concert with topoisomerase IIIα (TOPO IIIα) to resolve recombination intermediates c...

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Huvudupphovsmän: Wu, Leonard, Lung Chan, Kok, Ralf, Christine, Bernstein, Douglas A, Garcia, Patrick L, Bohr, Vilhelm A, Vindigni, Alessandro, Janscak, Pavel, Keck, James L, Hickson, Ian D
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2005
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176466/
https://ncbi.nlm.nih.gov/pubmed/15990871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600740
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