The HRDC domain of BLM is required for the dissolution of double Holliday junctions

Bloom's syndrome is a hereditary cancer-predisposition disorder resulting from mutations in the BLM gene. In humans, BLM encodes one of five members of the RecQ helicase family. One function of BLM is to act in concert with topoisomerase IIIα (TOPO IIIα) to resolve recombination intermediates c...

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Autores principales: Wu, Leonard, Lung Chan, Kok, Ralf, Christine, Bernstein, Douglas A, Garcia, Patrick L, Bohr, Vilhelm A, Vindigni, Alessandro, Janscak, Pavel, Keck, James L, Hickson, Ian D
Formato: Artigo
Lenguaje:Inglês
Publicado: 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176466/
https://ncbi.nlm.nih.gov/pubmed/15990871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600740
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