The HRDC domain of BLM is required for the dissolution of double Holliday junctions

Bloom's syndrome is a hereditary cancer-predisposition disorder resulting from mutations in the BLM gene. In humans, BLM encodes one of five members of the RecQ helicase family. One function of BLM is to act in concert with topoisomerase IIIα (TOPO IIIα) to resolve recombination intermediates c...

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Autori principali: Wu, Leonard, Lung Chan, Kok, Ralf, Christine, Bernstein, Douglas A, Garcia, Patrick L, Bohr, Vilhelm A, Vindigni, Alessandro, Janscak, Pavel, Keck, James L, Hickson, Ian D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176466/
https://ncbi.nlm.nih.gov/pubmed/15990871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600740
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