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Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila

Bcl-2 family proteins regulate cell death through the mitochondrial apoptotic pathway. Here, we show that the Drosophila Bax-like Bcl-2 family protein Drob-1 maintains mitochondrial function to protect cells from neurodegeneration. A pan-neuronal knockdown of Drob-1 results in lower locomotor activi...

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Bibliografske podrobnosti
Main Authors: Senoo-Matsuda, Nanami, Igaki, Tatsushi, Miura, Masayuki
Format: Artigo
Jezik:Inglês
Izdano: 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176450/
https://ncbi.nlm.nih.gov/pubmed/16001086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600721
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