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Origin and evolution of the archaeo-eukaryotic primase superfamily and related palm-domain proteins: structural insights and new members

We report an in-depth computational study of the protein sequences and structures of the superfamily of archaeo-eukaryotic primases (AEPs). This analysis greatly expands the range of diversity of the AEPs and reveals the unique active site shared by all members of this superfamily. In particular, it...

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Autors principals: Iyer, Lakshminarayan M., Koonin, Eugene V., Leipe, Detlef D., Aravind, L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1176014/
https://ncbi.nlm.nih.gov/pubmed/16027112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki702
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