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Creation and disruption of protein features by alternative splicing - a novel mechanism to modulate function

BACKGROUND: Alternative splicing often occurs in the coding sequence and alters protein structure and function. It is mainly carried out in two ways: by skipping exons that encode a certain protein feature and by introducing a frameshift that changes the downstream protein sequence. These mechanisms...

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Autors principals: Hiller, Michael, Huse, Klaus, Platzer, Matthias, Backofen, Rolf
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175989/
https://ncbi.nlm.nih.gov/pubmed/15998447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2005-6-7-r58
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