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Exonization of AluYa5 in the human ACE gene requires mutations in both 3′ and 5′ splice sites and is facilitated by a conserved splicing enhancer
Ancient Alu elements have been shown to be included in mature transcripts by point mutations that improve their 5′ or 3′ splice sites. We have examined requirements for exonization of a younger, disease-associated AluYa5 in intron 16 of the human ACE gene. A single G>C transversion in position −3...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1175817/ https://ncbi.nlm.nih.gov/pubmed/16027113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki707 |
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