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Exonization of AluYa5 in the human ACE gene requires mutations in both 3′ and 5′ splice sites and is facilitated by a conserved splicing enhancer

Ancient Alu elements have been shown to be included in mature transcripts by point mutations that improve their 5′ or 3′ splice sites. We have examined requirements for exonization of a younger, disease-associated AluYa5 in intron 16 of the human ACE gene. A single G>C transversion in position −3...

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Detalhes bibliográficos
Main Authors: Lei, Haixin, Day, Ian N. M., Vořechovský, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175817/
https://ncbi.nlm.nih.gov/pubmed/16027113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki707
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