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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

To study HIV-1 escape from a coreceptor antagonist, the R5 primary isolate CC1/85 was passaged in peripheral blood mononuclear cells with increasing concentrations of the CCR5-specific small molecule inhibitor, AD101. By 19 passages, an escape mutant emerged with a >20,000-fold resistance to AD101....

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Trkola, Alexandra, Kuhmann, Shawn E., Strizki, Julie M., Maxwell, Elizabeth, Ketas, Tom, Morgan, Tom, Pugach, Pavel, Xu, Serena, Wojcik, Lisa, Tagat, Jayaram, Palani, Anandan, Shapiro, Sherry, Clader, John W., McCombie, Stuart, Reyes, Gregory R., Baroudy, Bahige M., Moore, John P.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2002
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117571/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782552/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012519099
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