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HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

To study HIV-1 escape from a coreceptor antagonist, the R5 primary isolate CC1/85 was passaged in peripheral blood mononuclear cells with increasing concentrations of the CCR5-specific small molecule inhibitor, AD101. By 19 passages, an escape mutant emerged with a >20,000-fold resistance to AD101....

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Sábháilte in:
Foilsithe in:Proc Natl Acad Sci U S A
Príomhchruthaitheoirí: Trkola, Alexandra, Kuhmann, Shawn E., Strizki, Julie M., Maxwell, Elizabeth, Ketas, Tom, Morgan, Tom, Pugach, Pavel, Xu, Serena, Wojcik, Lisa, Tagat, Jayaram, Palani, Anandan, Shapiro, Sherry, Clader, John W., McCombie, Stuart, Reyes, Gregory R., Baroudy, Bahige M., Moore, John P.
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: National Academy of Sciences 2002
Ábhair:
Biological Sciences
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117571/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782552/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012519099
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