Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor δ (PPARδ) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality. Surviving PPARδ(−/−) mice exhibit a striking reduction in adiposity relative to wild-type levels....

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Barak, Yaacov, Liao, Debbie, He, Weimin, Ong, Estelita S., Nelson, Michael C., Olefsky, Jerrold M., Boland, Richard, Evans, Ronald M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117556/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11756685/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012610299
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