Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias

Mammary anlagen are formed in the embryo as a derivative of the epidermis, a process that is controlled by Lef-1 and therefore possibly by β-catenin. To investigate the role of β-catenin signaling in mammary alveolar epithelium, we have stabilized endogenous β-catenin in differentiating alveolar epi...

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Autors principals: Miyoshi, Keiko, Shillingford, Jonathan M., Le Provost, Fabienne, Gounari, Fotini, Bronson, Roderick, von Boehmer, Harald, Taketo, Makoto M., Cardiff, Robert D., Hennighausen, Lothar, Khazaie, Khashayarsha
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2002
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC117542/
https://ncbi.nlm.nih.gov/pubmed/11773619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.012414099
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