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Activation of β-catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias

Mammary anlagen are formed in the embryo as a derivative of the epidermis, a process that is controlled by Lef-1 and therefore possibly by β-catenin. To investigate the role of β-catenin signaling in mammary alveolar epithelium, we have stabilized endogenous β-catenin in differentiating alveolar epi...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Miyoshi, Keiko, Shillingford, Jonathan M., Le Provost, Fabienne, Gounari, Fotini, Bronson, Roderick, von Boehmer, Harald, Taketo, Makoto M., Cardiff, Robert D., Hennighausen, Lothar, Khazaie, Khashayarsha
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117542/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11773619/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.012414099
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