Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption

Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families: the matrix metalloproteinases (MMPs) are responsible for cartilage collagen breakdown, and enzymes from the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin motifs) family mediate ca...

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Detalhes bibliográficos
Principais autores: Young, David A, Lakey, Rachel L, Pennington, Caroline J, Jones, Debra, Kevorkian, Lara, Edwards, Dylan R, Cawston, Timothy E, Clark, Ian M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174946/
https://ncbi.nlm.nih.gov/pubmed/15899037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1702
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