Rational design of aggregation-resistant bioactive peptides: Reengineering human calcitonin

A high propensity to aggregate into intractable deposits is a common problem limiting the production and use of many peptides and proteins in a wide range of biotechnological and pharmaceutical applications. Many therapeutic polypeptides are frequently abandoned at an early stage in their developmen...

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Detaylı Bibliyografya
Asıl Yazarlar: Fowler, Susan B., Poon, Stephen, Muff, Roman, Chiti, Fabrizio, Dobson, Christopher M., Zurdo, Jesús
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2005
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174920/
https://ncbi.nlm.nih.gov/pubmed/16006528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501215102
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