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ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif
ArfGAP1 promotes GTP hydrolysis in Arf1, a small G protein that interacts with lipid membranes and drives the assembly of the COPI coat in a GTP-dependent manner. The activity of ArfGAP1 increases with membrane curvature, suggesting a negative feedback loop in which COPI-induced membrane deformation...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1173154/ https://ncbi.nlm.nih.gov/pubmed/15944734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600714 |
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