ArfGAP1 generates an Arf1 gradient on continuous lipid membranes displaying flat and curved regions

ArfGAP1, which promotes GTP hydrolysis on the small G protein Arf1 on Golgi membranes, interacts preferentially with positively curved membranes through its amphipathic lipid packing sensor (ALPS) motifs. This should influence the distribution of Arf1-GTP when flat and curved regions coexist on a co...

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Main Authors: Ambroggio, Ernesto, Sorre, Benoît, Bassereau, Patricia, Goud, Bruno, Manneville, Jean-Baptiste, Antonny, Bruno
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824456/
https://ncbi.nlm.nih.gov/pubmed/19927117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.341
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