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Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions.

Cobalt ions (Co2+) are potent inducers of haem oxygenase in liver and inhibit microsomal drug oxidation probably by depleting microsomal haem and cytochrome P-450. Complexing of Co2+ ions with cysteine or glutathione (GSH) blocked ability of the former to induce haem oxygenase. When hepatic GSH cont...

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Dettagli Bibliografici
Autori principali: Maines, M D, Kappas, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1976
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1172683/
https://ncbi.nlm.nih.gov/pubmed/819007
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