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An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene
We have investigated a herpes simplex virus mutant that expresses low levels of thymidine kinase (TK), a phenotype associated with drug resistance and pathogenicity, despite a single-base deletion in the gene. Using a dual-reporter system, a 39-nt sequence including the mutation was shown to direct...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2005
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1172279/ https://ncbi.nlm.nih.gov/pubmed/15972803 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504132102 |
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