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APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast
Human cells harbor a variety of factors that function to block the proliferation of foreign nucleic acid. The APOBEC3G enzyme inhibits the replication of retroviruses by deaminating nascent retroviral cDNA cytosines to uracils, lesions that can result in lethal levels of hypermutation. Here, we demo...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1172225/ https://ncbi.nlm.nih.gov/pubmed/16000409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501694102 |
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