Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277

Using a bio-oligo pull-down DNA-binding assay we investigated the binding capacity of endogenous, DNA damage-induced p53 in human diploid fibroblasts to several p53-responsive elements (REs) present in p53-regulated genes. During the course of p53 accumulation, we observed a decrease in p53 binding...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Buzek, Jiri, Latonen, Leena, Kurki, Sari, Peltonen, Karita, Laiho, Marikki
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2002
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117181/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12034820/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/30.11.2340
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