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The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression.

Inhibition of apoptosis is an important characteristic of oncogenic transformation. The Par-4 gene product has recently been shown to be upregulated in cells undergoing apoptotic cell death, and its ectopic expression was shown to be critical in apoptosis. We demonstrate that expression of oncogenic...

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Detalhes bibliográficos
Main Authors: Barradas, M, Monjas, A, Diaz-Meco, M T, Serrano, M, Moscat, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171699/
https://ncbi.nlm.nih.gov/pubmed/10562548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.22.6362
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