A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.

We describe the isolation and molecular characterization of seven distinct proteins present in human [U4/U6.U5] tri-snRNPs. These proteins exhibit clear homology to the Sm proteins and are thus denoted LSm (like Sm) proteins. Purified LSm proteins form a heteromer that is stable even in the absence...

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Bibliographic Details
Main Authors: Achsel, T, Brahms, H, Kastner, B, Bachi, A, Wilm, M, Lührmann, R
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171645/
https://ncbi.nlm.nih.gov/pubmed/10523320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.20.5789
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