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Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication.
The Cdc7-Dbf4 kinase is essential for regulating initiation of DNA replication in Saccharomyces cerevisiae. Previously, we identified a human Cdc7 homolog, HsCdc7. In this study, we report the identification of a human Dbf4 homolog, HsDbf4. We show that HsDbf4 binds to HsCdc7 and activates HsCdc7 ki...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171637/ https://ncbi.nlm.nih.gov/pubmed/10523313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.20.5703 |
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