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WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene.
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger transcription factor that has been demonstrated to negatively regulate several growth factor and cognate receptor genes. However, inconsistent with its tumor suppressor function, WT1 has also been demonstrated to be required to inhibi...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
1999
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171475/ https://ncbi.nlm.nih.gov/pubmed/10406804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.14.3990 |
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