Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.

Enforced expression of Id3, which has the capacity to inhibit many basic helix-loop-helix (bHLH) transcription factors, in human CD34(+) hematopoietic progenitor cells that have not undergone T cell receptor (TCR) gene rearrangements inhibits development of the transduced cells into TCRalpha beta an...

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Détails bibliographiques
Auteurs principaux: Blom, B, Heemskerk, M H, Verschuren, M C, van Dongen, J J, Stegmann, A P, Bakker, A Q, Couwenberg, F, Res, P C, Spits, H
Format: Artigo
Langue:Inglês
Publié: 1999
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171360/
https://ncbi.nlm.nih.gov/pubmed/10329625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.10.2793
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