An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.

beta-catenin plays an essential role in the Wingless/Wnt signaling cascade and is a component of the cadherin cell adhesion complex. Deregulation of beta-catenin accumulation as a result of mutations in adenomatous polyposis coli (APC) tumor suppressor protein is believed to initiate colorectal neop...

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Detalhes bibliográficos
Main Authors: Kitagawa, M, Hatakeyama, S, Shirane, M, Matsumoto, M, Ishida, N, Hattori, K, Nakamichi, I, Kikuchi, A, Nakayama, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171323/
https://ncbi.nlm.nih.gov/pubmed/10228155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.9.2401
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