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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin.
beta-catenin plays an essential role in the Wingless/Wnt signaling cascade and is a component of the cadherin cell adhesion complex. Deregulation of beta-catenin accumulation as a result of mutations in adenomatous polyposis coli (APC) tumor suppressor protein is believed to initiate colorectal neop...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1999
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171323/ https://ncbi.nlm.nih.gov/pubmed/10228155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.9.2401 |
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