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Conformation of the Bax C-terminus regulates subcellular location and cell death.
Bax, a pro-apoptotic member of the Bcl-2 family, translocates from the cytosol to the mitochondria during programmed cell death. We report here that both gain-of-function and loss-of-function mutations can be achieved by altering a single amino acid in the Bax hydrophobic C-terminus. The properly mu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1171316/ https://ncbi.nlm.nih.gov/pubmed/10228148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.9.2330 |
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