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Deletion of a region that is a candidate for the difference between the deletion forms of hereditary persistence of fetal hemoglobin and deltabeta-thalassemia affects beta- but not gamma-globin gene expression.

The analysis of a number of cases of beta-globin thalassemia and hereditary persistence of fetal hemoglobin (HPFH) due to large deletions in the beta-globin locus has led to the identification of several DNA elements that have been implicated in the switch from human fetal gamma- to adult beta-globi...

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Autori principali: Calzolari, R, McMorrow, T, Yannoutsos, N, Langeveld, A, Grosveld, F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171187/
https://ncbi.nlm.nih.gov/pubmed/10022837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.4.949
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