The structure and function of a foot-and-mouth disease virus-oligosaccharide receptor complex.

Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a specific highly abundant motif of sulfated sugars. The binding site is a shallow depression on the virion surfa...

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Detalhes bibliográficos
Main Authors: Fry, E E, Lea, S M, Jackson, T, Newman, J W, Ellard, F M, Blakemore, W E, Abu-Ghazaleh, R, Samuel, A, King, A M, Stuart, D I
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1171147/
https://ncbi.nlm.nih.gov/pubmed/9927414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/18.3.543
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